{"id":46,"date":"2026-03-18T06:56:18","date_gmt":"2026-03-18T06:56:18","guid":{"rendered":"https:\/\/sadafmughal.de\/wordpress\/?page_id=46"},"modified":"2026-03-18T07:07:32","modified_gmt":"2026-03-18T07:07:32","slug":"research","status":"publish","type":"page","link":"https:\/\/sadafmughal.de\/wordpress\/index.php\/research\/","title":{"rendered":"Research"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<div class=\"wp-block-cover alignwide wp-duotone-unset-1\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"680\" class=\"wp-block-cover__image-background wp-image-52\" alt=\"\" src=\"https:\/\/sadafmughal.de\/wordpress\/wp-content\/uploads\/2026\/03\/website-1024x680.png\" data-object-fit=\"cover\" srcset=\"https:\/\/sadafmughal.de\/wordpress\/wp-content\/uploads\/2026\/03\/website-1024x680.png 1024w, https:\/\/sadafmughal.de\/wordpress\/wp-content\/uploads\/2026\/03\/website-300x199.png 300w, https:\/\/sadafmughal.de\/wordpress\/wp-content\/uploads\/2026\/03\/website-768x510.png 768w, https:\/\/sadafmughal.de\/wordpress\/wp-content\/uploads\/2026\/03\/website-1536x1020.png 1536w, https:\/\/sadafmughal.de\/wordpress\/wp-content\/uploads\/2026\/03\/website-2048x1360.png 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim\"><\/span><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<p>My research combines computational analysis of single\u2011cell and spatially resolved omics to map tumor heterogeneity and immune organization within the tumor microenvironment, with the goal of revealing mechanisms that shape anti\u2011tumor immunity and therapeutic response.<\/p>\n<p>Research highlights<\/p>\n<p>    * B cell biology and tertiary lymphoid structures (TLS): I use spatial and single\u2011cell omics datasets to study TLS organization, B cell phenotypic diversity, and how these features influence anti\u2011tumor immunity and responses to immunotherapy.<br \/>\n    * Extrachromosomal DNA (ecDNA) in cancer evolution: I examine ecDNA\u2011driven oncogene amplification and its role in creating intra\u2011tumor heterogeneity, transcriptional plasticity, and altered immune responses.<\/p>\n\n\n\n<p class=\"has-text-align-center has-large-font-size wp-block-paragraph\"><\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-46","page","type-page","status-publish"],"_links":{"self":[{"href":"https:\/\/sadafmughal.de\/wordpress\/index.php\/wp-json\/wp\/v2\/pages\/46","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sadafmughal.de\/wordpress\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sadafmughal.de\/wordpress\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sadafmughal.de\/wordpress\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sadafmughal.de\/wordpress\/index.php\/wp-json\/wp\/v2\/comments?post=46"}],"version-history":[{"count":7,"href":"https:\/\/sadafmughal.de\/wordpress\/index.php\/wp-json\/wp\/v2\/pages\/46\/revisions"}],"predecessor-version":[{"id":57,"href":"https:\/\/sadafmughal.de\/wordpress\/index.php\/wp-json\/wp\/v2\/pages\/46\/revisions\/57"}],"wp:attachment":[{"href":"https:\/\/sadafmughal.de\/wordpress\/index.php\/wp-json\/wp\/v2\/media?parent=46"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}